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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLN3 All Species: 15.76
Human Site: S208 Identified Species: 43.33
UniProt: Q13286 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q13286 NP_000077.1 438 47623 S208 G L T Q A G L S P Q Q T L L S
Chimpanzee Pan troglodytes XP_523328 352 38227 I133 P R V L V S G I C A A G S F D
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q61124 438 47755 S208 G L T Q A G L S P Q H T L L S
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514486 433 47507 S208 G L T Q A G L S P R Q T L L S
Chicken Gallus gallus
Frog Xenopus laevis NP_001086663 433 47849 S198 G L T E V G L S P R N S L L V
Zebra Danio Brachydanio rerio NP_001007307 446 49412 T199 A L T Q A G L T P Q V T L W I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_394336 415 45964 N190 S L T T W L S N E D T L L L M
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P47040 408 46365 D188 Y Q S L Q Q I D E A E D D Q L
Red Bread Mold Neurospora crassa Q7SC45 464 50477 K220 P L R A S A R K T Y E P I A N
Conservation
Percent
Protein Identity: 100 78.7 N.A. N.A. N.A. 84.9 N.A. N.A. 74.8 N.A. 57.3 50.6 N.A. N.A. 40.4 N.A. N.A.
Protein Similarity: 100 79.2 N.A. N.A. N.A. 89.9 N.A. N.A. 85.1 N.A. 72.8 65.4 N.A. N.A. 59.8 N.A. N.A.
P-Site Identity: 100 0 N.A. N.A. N.A. 93.3 N.A. N.A. 93.3 N.A. 60 66.6 N.A. N.A. 26.6 N.A. N.A.
P-Site Similarity: 100 0 N.A. N.A. N.A. 93.3 N.A. N.A. 100 N.A. 80 73.3 N.A. N.A. 33.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 38.8 26.9
Protein Similarity: N.A. N.A. N.A. N.A. 53.2 42
P-Site Identity: N.A. N.A. N.A. N.A. 0 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. 20 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 0 12 45 12 0 0 0 23 12 0 0 12 0 % A
% Cys: 0 0 0 0 0 0 0 0 12 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 12 0 12 0 12 12 0 12 % D
% Glu: 0 0 0 12 0 0 0 0 23 0 23 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 12 0 % F
% Gly: 45 0 0 0 0 56 12 0 0 0 0 12 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 12 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 12 12 0 0 0 0 12 0 12 % I
% Lys: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % K
% Leu: 0 78 0 23 0 12 56 0 0 0 0 12 67 56 12 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 12 % M
% Asn: 0 0 0 0 0 0 0 12 0 0 12 0 0 0 12 % N
% Pro: 23 0 0 0 0 0 0 0 56 0 0 12 0 0 0 % P
% Gln: 0 12 0 45 12 12 0 0 0 34 23 0 0 12 0 % Q
% Arg: 0 12 12 0 0 0 12 0 0 23 0 0 0 0 0 % R
% Ser: 12 0 12 0 12 12 12 45 0 0 0 12 12 0 34 % S
% Thr: 0 0 67 12 0 0 0 12 12 0 12 45 0 0 0 % T
% Val: 0 0 12 0 23 0 0 0 0 0 12 0 0 0 12 % V
% Trp: 0 0 0 0 12 0 0 0 0 0 0 0 0 12 0 % W
% Tyr: 12 0 0 0 0 0 0 0 0 12 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _